Four heterozygous missense variants that segregate with endometriosis remained after filtering: c.1238C>T, p.(Pro413Leu) in fibroblast growth factor receptor 4 (FGFR4), c.5065C>T, p.(Arg1689Trp) in sodium leak channel, non-selective (NALCN), c.2086G>A, p.(Val696Met) in neuron navigator 2 (NAV2), and c.1196C>T, p.(Thr399Met) in SWI-/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a like 1 (SMARCAL1) (Table 2). The gene discussed is NALCN; the disease is endometriosis.