CACNA2D4 and Alzheimer disease: Based on literature search, 5 of these genes (Flt1, Calponin 3, Igf1, Cacna2d4, Celsr) were reported with experimentally confirmed functions related with MG/MΦ migration and phagocytosis, which was used to establish a model for potential mechanism underlying HHcy-suppressed Aβ phagocytosis in microglia in AD (Fig. 6C).