We identified 3 HHcy-altered phagocytic AD MG DEGs (Ctse, Flt1, Hsp70), 3 HHcy-altered Aβ+ MG DEGs (Ch25h, Calponin 3, Igf1), 3 HHcy-altered MG phagocytic modifier genes (Cacna2d4, Celsr3, Nek5, Tpk1), and 1 HHcy-altered hypomethylation-upregulated phagocytic AD MG DM/EG Cacna2d4, which was also identified as a HHcy-altered MG phagocytic modifier gene (Fig. 6B1,B2,B3). Here, CTSE is linked to Alzheimer disease.