IGF1 and Alzheimer disease: Their phagocytosis and MG/MΦ activation functions were supported by published studies, and their determined subcellular localizations based on GeneCards are presented in Supplemental Figure S2F. Finally, we identified Igf1, as the only GWAS-mapped phagocytic AD MG DEG, which was reduced by 1.79-fold in MG isolated from our HHcy Cbs−/− mice.