Among the 16 endocytosis-related AD MG DEGs common in both species, we recognized 8 upregulated genes including 5 Aβ clearance-related genes (TMEM163, APOE, TLR2, TREM2, and C3), glial proliferation gene CACNA1A, actin assembly and cargo trafficking gene MYO1E, and cell survival/polarization gene CD63 and 4 downregulated genes including M1 polarization genes PRKCA and PLD1 and exocytosis and autophagy genes SYT1 and UBC, based on their consistent expression direction in both species. Here, APOE is linked to Alzheimer disease.