APP and Alzheimer disease: Using identical selecting criteria (FC > 1.5 and an adjusted p-value < 0.05), we selected total 489 DEGs from 4 human MG RNA-sequencing datasets (89, 218, 108, and 74) and 4618 DEGs from 7 mouse MG RNA-sequencing datasets (915, 275, 285, 349, 249, 399, and 2146) as detailed in Fig. 3A and B. Five mouse AD models were utilized, all characterized by mutations in APP/PS1 and elevated levels of the Aβ1-42/Aβ1-42 ratio.