Their expression profiles in human and mouse AD models are presented in Supplemental Figures S2C and D. Interestingly, human and mouse AD shared 4 GWAS-mapped AD MG DEGs, 3 of which were upregulated in both human and mouse AD (TMEM163, APOE, TREM2), all possessing the phagocytic function. The gene discussed is APOE; the disease is Alzheimer disease.