C3 and Alzheimer disease: Among the 16 endocytosis-related AD MG DEGs common in both species, we recognized 8 upregulated genes including 5 Aβ clearance-related genes (TMEM163, APOE, TLR2, TREM2, and C3), glial proliferation gene CACNA1A, actin assembly and cargo trafficking gene MYO1E, and cell survival/polarization gene CD63 and 4 downregulated genes including M1 polarization genes PRKCA and PLD1 and exocytosis and autophagy genes SYT1 and UBC, based on their consistent expression direction in both species.