FOXP3 and leukemia: For instance, the poly(A) signal alters from AAUAAA to AAUGAA in FOXP3 leads to an immune dysregulation syndrome (Bennett et al. 2001); widespread poly(A) site switch to intronic loci inactivates tumor suppressor genes in leukemia (Lee et al. 2018) and extensive APA were found associated with leukemia at the single cell level (Ye et al. 2019a).