The cerebral cortex underlies the higher-order cognition of humans, and GWASs indicate that intronic variants of FOXO3 are correlated with the surface area of the human cerebral cortex [52, 53], cortical thickness [53, 54], brain volume [55], vertex-wise sulcal depth [54], intelligence [56, 57], and schizophrenia [58, 59]. This evidence concerns the gene FOXO3 and schizophrenia.