Among CLBC patients, the univariate Cox analysis found that year of diagnosis, age at diagnosis, race, marital status, grade, tumor stage, node stage, ER status, PR status, surgery procedure, and chemotherapy were associated with the BCSS and OS, while HER-2 status and radiotherapy were only associated with OS but not BCSS (Supplementary Table 4). Here, ESR1 is linked to neoplasm.