A retrospective study of 545 patients revealed that in the neoadjuvant setting, the pCR rate with TCbHPy was superior to that with TCbH and comparable to that with TCbHP (docetaxel, carboplatin, trastuzumab, pertuzumab) in HER2-positive local ABC [76]. The gene discussed is ERBB2; the disease is aneurysmal bone cyst.