ERBB2 and breast cancer: We researched the use of pyrotinib in neoadjuvant therapy for HER2-positive BC: 19 patients received four cycles of ECP (epirubicin, cyclophosphamide, pyrotinib) and then four cycles of THP (docetaxel, trastuzumab, pyrotinib) before surgery, and tpCR was achieved in 73.7% (95% CI 48.8–90.9), and ORR was 100% (95% CI 82.4–100) of cases [72].