ARPC5 and central nervous system cancer: Second, we studied the clinical significance of ARPC5 expression changes in glioma patients and found that high expression level of ARPC5 were significantly related to several clinical features, such as gender, histological grade, chemotherapy status, relapses, IDH mutation, 1p/19q codeletion, and MGMTp methylation, suggesting that its overexpression may play a catalytic role in the clinical progress of glioma.