KEGG pathway analysis showed that ARPC5 were mainly enriched in multiple tumor-related signaling pathways, such as proteoglycans in cancer, small cell lung cancer, pancreatic cancer, non-small cell lung cancer, glioma, melanoma, acute myeloid leukemia, and renal cell carcinoma (Fig. 4D); the full information is included in Supplementary Table S1. This evidence concerns the gene ARPC5 and melanoma.