The 2020 European Atherosclerosis Society task force consensus statement on rare dyslipidemias also does not recommend the use of TPE in chylomicronemia syndrome with AP, with the possible exception of controlling severe HTG due to monogenic chylomicronemia during pregnancy; it only recommends fasting and intravenous insulin for patients with diabetes [26]. The gene discussed is INS; the disease is alkaline phosphatase measurement.