In vitro experiments using genetically modified tumor cell lines demonstrated that NF-ĸB is essential for p53-mediated cell death54, and additional studies reported biochemical evidence that p53 may not necessarily stimulate the proapoptotic activity of NF-ĸB, but rather neutralizes its capacity to induce the expression of antiapoptotic genes55,56. The gene discussed is TP53; the disease is neoplasm.