Interestingly, several differentially expressed genes including ADAMTS2 for cognitive decline, NPNT for all four traits, RERG for \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β-Amyloid and global AD pathology, as well as MEIS3 for cognitive decline and tangle density that were identified in the discovery data were replicated in the validation datasets of DLPFC and CNS tissues. This evidence concerns the gene ADAMTS2 and Alzheimer disease.