DAPK1 and Alzheimer disease: Also, for the pathways significantly enriched with top 100 differentially expressed genes of tangle density (Fig. 5B), Death-Associated Protein Kinase 1 in DAPk family (FDR = 5.98 × 10–3) that plays a critical role in deregulation in AD thus manipulating DAPK1 activity and/or expression could be a promising drug target in AD45.