AKT1 and breast cancer: Baicalein increased autophagy-related genes LC3B and Beclin-1 and also induced apoptosis in BC in vitro and in vivo (specifically, MCF-7 and MDA-MB-231 cells), while the authors described also the effects on numerous signaling molecules and pathways, including downregulated NF-κB, p-IκB, or p-AKT but upregulated IκB [189].