Furthermore, we observed a decline in the ability of tumor-infiltrating CD8+ T cells to produce inflammatory cytokines interferon-gamma (IFN-γ) in stressed mice, in addition to the decrease in their numbers (Fig. 1e–h), despite no significant changes were observed in the levels of cytolytic molecule granzyme B (GZMB) and tumor necrosis factor α (TNF-α) (Supplementary Fig. 1h). This evidence concerns the gene CD8A and neoplasm.