IL-24 and its receptors are expressed and induced in human wounds, but there are conflicting reports of an inhibitory effect on keratinocyte migration and proliferation.5 Also contradictory are reports on the effect of IL-24 on vessels, with most data showing an induction of proliferation but blocking of differentiation.5 IL-24-induction has been implicated in the pathogenesis of psoriasis vulgaris, airway damage in severe COVID-19 and in ulcerative colitis, raising the question whether IL-24 serves as an eminent signal for repair in organs with epithelial layers. The gene discussed is IL24; the disease is ulcerative colitis.