To substantiate the importance of SMARCE1 functionality in neural development, we draw attention to the phenomenon of aberrant neural differentiation caused by SMARCE1 missense mutation leading to debilitating neurological disorders such as Coffin-Siris syndrome.2 The neurodevelopment implication can be widened if the argument covers the essence of mitotic docking of SMARCB1 and other SWI/SNF subunits. The gene discussed is SMARCE1; the disease is nervous system disorder.