TDP1 and spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1: Mutations in TDP1 and SPRTN lead to the neurological disorder spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) [27] and Ruijs–Aalfs syndrome (RJALS) characterized by premature ageing and early onset liver cancer [28], respectively.