Interestingly, CXCL13+CD4+ T cells but not CXCL13+ CD8 T cells accumulate in early TLSs of ovarian cancers whereas, in the matured TLSs with T–B segregation, CD21+ follicular dendritic cell (FDC)-like stroma cells, rather than CD4+ T cells, expressed CXCL13 (44). This evidence concerns the gene CD4 and ovarian cancer.