Among the top 10 significantly upregulated genes, 5 have been associated with tumor progression, metastasis, or recurrence (CALB2, ref. 51, ECM1, refs. 52, 53; TNIK, ref. 54; IGFBP4, ref. 55; and TCN1, ref. 56); Supplemental Figure 7B), including TNIK (57) and IGFBP4 (58), which are reported downstream targets of Yap. This evidence concerns the gene TCN1 and neoplasm.