Indeed, transfer of activated WT OTI CD8+ T cells had a negligible effect on tumor growth or long-term survival, whereas transfer of either WT/SA or SA/SA OTI CD8+ T cells significantly inhibited both tumor growth (Figure 6A) and prolonged survival (Figure 6B), the latter with a significant dose response effect (survival log-rank Mantel-Cox; P = 0.0085 for WT versus WT/SA cells, P = 0.00002 for WT versus SA/SA cells, and P = 0.027 between WT/SA and SA/SA cells). Here, CD8A is linked to neoplasm.