An analysis of mutations in MYH7 that result in hypertrophic cardiomyopathy (HCM) and myosinopathies shows that mutations that cause HCM are distributed throughout the molecule, whereas those causing myosinopathies are mainly restricted to a specific region within LMM, between residues 1400 and 1700 (Figure 1C). This evidence concerns the gene MYH7 and hypertrophic cardiomyopathy.