Malaria is most commonly diagnosed in the clinic using rapid diagnostic tests (RDTs) that were thought to reliably identify P. falciparum infections, but reports of the loss of expression of histidine-rich protein 2 (HRP2), the protein commonly used in RDTs, have evidenced high percentages of false-negative P. falciparum diagnoses in some endemic areas (6). This evidence concerns the gene HDGFL2 and malaria.