Given that USP47 correlated with the Treg signature in human CRC and GC tissues, we inoculated Usp47+/+Foxp3-Cre and Usp47fl/flFoxp3-Cre mice with MC38 murine colon cancer cells to examine the functional importance of USP47 in tumor-infiltrating Tregs. The gene discussed is FOXP3; the disease is colorectal carcinoma.