ADAM10 and Sepsis: Upon infection of WT and VE-Cad ADAM10–/– mice with these pathogens, VE-Cad ADAM10–/– mice were protected against lethal sepsis caused by P. aeruginosa (Figure 3A) and S. pneumoniae (Figure 3B), but not sepsis due to GBS (Figure 3C) or C. albicans (Figure 3D).