Although WT control mice (VE-Cad ADAM10+/+) succumbed to sepsis induced by i.v. inoculation of 1 × 108 CFU S. aureus USA300/LAC, endothelial ADAM10-knockout mice (VE-Cad ADAM10–/–) were protected against lethal infection (Figure 1B). Here, ADAM10 is linked to Sepsis.