Upon infection of WT and VE-Cad ADAM10–/– mice with these pathogens, VE-Cad ADAM10–/– mice were protected against lethal sepsis caused by P. aeruginosa (Figure 3A) and S. pneumoniae (Figure 3B), but not sepsis due to GBS (Figure 3C) or C. albicans (Figure 3D). The gene discussed is ADAM10; the disease is infection.