Using LASSO-univariate Cox analysis, we identified 6 ARGs that were associated with HCC prognosis, consisting of 4 risk factors (E2F1, ITGA5, SRC, TFDP1) and 2 favorable factors (PDK4, STK11) (Figure 2A–2C). The gene discussed is TFDP1; the disease is hepatocellular carcinoma.