Additionally, the copy number analysis of ARGs in HCC showed significant amplification of most ARGs, such as MCL1, PTK2, TFDP1, PTRH2, SNAI2, and PIK3CA, while several genes including MTOR, STK11, BCL2, MAP3K7, AKT1, CHEK2, and MYBBP1A were significantly missing (Figure 1C). Here, PIK3CA is linked to hepatocellular carcinoma.