In our study, eriocitrin treatment obviously decreased the viability, deterred wound closure, upregulated epithelial biomarker (E-cadherin) expression, downregulated mesenchymal biomarkers (N-cadherin and vimentin) expression in A549 and H1299 cells, which are combined to convey the truth that eriocitrin hold promise to anti-cancer metastasis for anti-EMT procedure. The gene discussed is VIM; the disease is cancer.