Deactivation of the HMGA2 (formerly HMGI/C) gene leads to a dwarf phenotype with characteristic hypoplasia in the mesenchymal tissue; thus, HMGA2 has an important role in mammalian growth and development.12 Both HMGA1 and HMGA2 are suppressed or absent in most adult differentiated tissues,13,14 although their expression is observed in embryonic tissues.15,16 There are studies evaluating HMGA2 protein expression in malignant epithelial tumors such as stomach,17 colon,18 breast,19 lung,20 bladder,21 skin,22 and kidney23 carcinomas. This evidence concerns the gene HMGA2 and carcinoma.