c-Met isfound on high levels on the surface of colorectal adenoma-carcinomacells at early stages of the disease, potentially being a biomarkerfor the detection of neoplasia using fluorescence-guided endoscopy.Bearing this target in mind, the probe GE-137 (later known as EM-137)was developed as a high-affinity probe for c-Met.16 GE-137 was used in a first in-human pilot study demonstratingthe safety of intravenous injection and its suitability for detectionof neoplastic polyps, including some that were not detected by visiblelight. This evidence concerns the gene MET and neoplasm.