c-Met isfound on high levels on the surface of colorectal adenoma-carcinomacells at early stages of the disease, potentially being a biomarkerfor the detection of neoplasia using fluorescence-guided endoscopy.Bearing this target in mind, the probe GE-137 (later known as EM-137)was developed as a high-affinity probe for c-Met.16 GE-137 was used in a first in-human pilot study demonstratingthe safety of intravenous injection and its suitability for detectionof neoplastic polyps, including some that were not detected by visiblelight. The gene discussed is MET; the disease is colorectal adenoma.