TNF and glycogen storage disease VI: A notable example reportedthe generation of a fluorescent antibody for membrane-bound tumornecrosis factor (mTNF) and subsequent imaging in 25 patients withCrohn’s disease (NCT01275508).57 TNF-α has a critical role in the immunopathogenesis of Crohn’sdisease, and several anti-TNF therapies have already been approved;however, there are few predictive biomarkers that can successfullyidentify responders over nonresponders.