In addition, PBMCs from HD (Healthy Donor), CHB, and CHC patients were stimulated with HBVcc and HCVcc; we observed that HBVcc induced the production of IL-18 and IFN-γ in PBMCs from CHB, CHC patients, and HD, while HCVcc did not have these effects in PBMCs from CHB, CHC patients, and HD. Here, IL18 is linked to cryohydrocytosis.