COBLL1 and type 2 diabetes mellitus: We then searched the Type 2 Diabetes Knowledge Portal (https://t2d.hugeamp.org/) for SNPs that are associated with one or more glycemia-related traits (see Table 2) with a p-value <10–8, and are located within ±100 kbp of the homologous gene (e.g. COBLL1, Figure 6A), or in regions that contact the gene’s promoter region (determined using human islet promoter-capture HiC data; Miguel-Escalada et al., 2019) as illustrated by ACP1 (Figure 6B).