A key ligand regulating vascular homeostasis, BMP9 (also known as GDF2), is synthesized in the liver and contributes to liver fibrosis in adult sinusoids downstream of LSEC de-differentiation (Bidart et al., 2012; Breitkopf-Heinlein et al., 2017). This evidence concerns the gene GDF2 and Hepatic fibrosis.