Small‐molecule modulators of aerobic glycolysis (e.g. dichloroacetate), as well as Shh and Notch signaling pathways (e.g. vismodegib and DAPT, respectively), that are widely tried as potent anti‐cancer agents, have also been shown to be endowed with significant anti‐platelet/anti‐thrombotic attributes [4, 5]. Here, SHH is linked to cancer.