The phosphorylation of KDM1A Ser683, PGK1 T243, Atoh1 tyrosine 78, YTHDF2 Ser39, and Thr381 can promote tumorigenesis, and if we can effectively control the phosphorylation of these proteins, we can prevent the development of glioma. The gene discussed is ATOH1; the disease is central nervous system cancer.