It is characterized by clonal proliferation and accumulation of malignant B-lymphocytes in the peripheral blood and in immune tissues such as lymphoid organs and bone marrow [2]. It has been reported that B cells, isolated from peripheral blood of CLL patients, express high and intermediate levels of TLR7 and TLR8, respectively [3]. This evidence concerns the gene TLR7 and B-cell chronic lymphocytic leukemia.