However, a strong association was found between genetic aberrations such as Tumor protein 53 (TP53)-dis and mutated-immunoglobulin heavy variable region (M-IGHV), which weren’t assigned in our study, and expression levels of mTOR and HIF-1α in CLL patients [20, 26, 27]. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.