However, an imbalance in the tetramer: monomer ratio can lead to the preponderance of aggregating forms evolving from oligomers to polymers that could converge into fibrous filaments in the form of Lewy bodies and Lewy neurites19 As previously reported for AD, also in PD τ protein misfolding occurs, which leads to plaques formation.24 Here, TBXT is linked to Alzheimer disease.