Recent studies46 have shown that ISO can alleviate the inflammatory factor analysis and the degree of lipid peroxidation in rats with cerebral ischemia/reperfusion injury through the TGF‐β/Smad2/3 signaling pathway, reduce the hydrolytic activity of matrix metalloproteinases in brain tissue, reduce tight junction protein loss, and improve cerebral ischemia–reperfusion injury in rats. Here, SMAD2 is linked to Cerebral ischemia.