In this context, it has been described that allicin reduced inflammation caused by diabetic macroangiopathy in mice through the Nrf2-NF-κB pathway and improved osteoarthritis by downregulating PI3K/Akt/NF-κB signaling (Li et al., 2020; Qian et al., 2018). This evidence concerns the gene NFKB1 and osteoarthritis.