On the other hand, adiposity leads to the production of proinflammatory cytokines such as interleukin-6 (IL-6), interleukin 1-β (IL-1β), and tumor necrosis factor-alpha (TNF-α), which are closely related to renal cell dysfunction and insulin resistance (Markova et al., 2019). The gene discussed is TNF; the disease is Insulin resistance.