Changes in these lipid metabolites have been reported in non-alcoholic fatty liver disease, obesity, type 2 diabetes, and several cardiovascular diseases for which chronic inflammation is a major contributor.71 Because oxylipins are generated by the oxidation of different PUFAs through COX, LOX, and CYP pathways, we analyzed oxylipin profiles stratified by oxylipin's precursors and synthesis pathways. The gene discussed is PPIG; the disease is obesity due to melanocortin 4 receptor deficiency.