VPS35 and Parkinson disease: As a key protein of the retromer complex, VPS35 participates in a variety of possible mechanisms in the pathogenesis of PD, including affecting autophagy, the dynamic balance of mitochondria, neurosynaptic transmission, dopamine signaling pathway conduction, vesicle transport, other PD pathogenic protein interactions, etc. These findings suggest that increasing the expression level of VPS35 protein in neurons or enhancing its function may be a potential therapeutic target for the treatment of PD.