VPS35 is the core component of the retromer complex; it may play a role in the pathogenesis of Parkinson's disease (PD) by affecting autophagy, mitochondria, neurosynaptic transmission, dopamine signaling pathways, and so forth, and it can interact with other disease‐causing genes (PARKIN, LRRK2) of familial PD. Here, PRKN is linked to Parkinson disease.