In this study, based on the perspective of tyrosine metabolism, we found that the tyrosine metabolizing enzymes 4‐hydroxyphenylpyruvate dioxygenase (HPD), homogentisate 1,2‐dioxygenase (HGD), and fumarylacetoacetate hydrolase (FAH) were upregulated in more malignant glioma patients. The gene discussed is FAH; the disease is malignant glioma.