Age‐mediated accumulation of H3K4me2 at promoters of several stress response‐related genes is reported in the monkey brain prefrontal cortex, which, by activating transcription, increased the expression of the stress response‐related proteins UBX domain protein 4 (UBXN4), tuftelin 1 (TUFT1), and Solute carrier family 24, member 4 (SLC24A4), leading to cognitive decline.45 This evidence concerns the gene UBXN4 and Mental deterioration.