In a word, previous studies mainly concentrated on the roles of SAMSN1 in varieties of cancers such as gastric cancer,7 multiple myelomas (MM),9 colorectal cancer,10 hepatocellular carcinomas,11 and angioimmunoblastic T‐cell lymphoma,12 which indicated that SAMSN1 is closely associated with cancer and immune system disease. Here, SAMSN1 is linked to hepatocellular carcinoma.