In TCGA database, we found the expression of SFXN4 was higher in HCC tissues than in non-paired paracancerous non-tumor tissues (3.992 ± 0.576 vs. 3.247 ± 0.284, P < 0.001) (Figure 1C), and also compared to paired paracancerous non-tumor tissues (5.283 ± 0.556 vs 4.444 ± 0.335, P < 0.001) (Figure 1D). Here, SFXN4 is linked to hepatocellular carcinoma.