As the founding member of SFXN family, SFXN1 was firstly reported in the flexed-tail (f) mouse with sideroblastic anemia, due to the fact that sideroblastic anemia is characterized by mitochondrial iron accumulation, SFXN1 was therefore deemed as a protein related to mitochondrial iron transportation and utilization 6. The gene discussed is SFXN1; the disease is sideroblastic anemia.