Potential triggers that have been shown to induce immune cell activation, the secretion of proinflammatory cytokines (i.e., TNF-α, IL-17, IFN-γ) and the production of autoantibodies (i.e., anti-cyclic citrullinated peptides), leading to autoimmunity and bone destruction 44, 45. This evidence concerns the gene IFNG and Autoimmunity.