CXCR4 and Alzheimer disease: However, Guillemaud et al.68found that inhibition of the astrocyte JAK/STAT pathway did not reduce pathological amyloid deposition in 3xTg mice. This suggested that the treatment of AD by blocking the CXCR4‐mediated JAK/STAT pathway on astrocyte surface needs further experimental verification, but it is undoubtedly a potential treatment for AD.