USP18 and ischemia: With the establishment of BV2 microglial cells under oxygen and glucose deprivation (OGD) and middle cerebral artery occlusion (MCAO) in mice as models of ischemia, the results from Xiang and his partners suggested that the ubiquitin‐specific protease 18 (USP18) reduced HI injury via the suppression of microglial activation by negatively inhibiting the JAK‐STAT pathway.24