This study reveals that the Arf1‐ablated tumor cells induce anti‐tumor immune response through releasing oxLDL, HMGB1, and genomic DNA that form a super signal complex and activate the NF‐κB, NLRP3 inflammasome and cGAS‐STING triple pathways in DC for producing CCL5, IL‐1β, type I IFNs, and CXCL10 to simultaneously promote DC activation, T cell infiltration, cross‐priming and stemness. The gene discussed is HMGB1; the disease is neoplasm.