CGAS and neoplasm: cGAS acts as a cytosolic DNA sensor, both genomic DNA (gDNA) and mitochondrial DNA (mtDNA) bind to and activate cGAS to initiate downstream signaling.[35] To determine whether the tumor cell‐derived DNAs were involved in cGAS activation or not, we performed a pulldown assay to assess the DNA‐protein interaction in either the Arf1‐ablation‐stimulated or control DCs.