Taken together, these data demonstrated that the tumor‐derived HMGB1‐gDNA complex engaged in activation of the cGAS‐STING‐type I IFNs and NF‐κB pathways that further primed the inflammasome, which was finally activated by the tumor‐derived oxLDL in DCs. The gene discussed is NFKB1; the disease is neoplasm.