Altogether, we concluded that the Arf1‐ablated tumor cells were able to activate the NLRP3 inflammasome, cGAS‐STING, and NF‐κB pathways in DCs, the triple pathways together induced production of the cytokines and chemokines in the activated DCs to activate tumor immune microenvironment in the Arf1‐deficient‐tumors. This evidence concerns the gene NLRP3 and neoplasm.