Whereas this effect was mostly dependent on NLRP3, not Aim2, inflammasome, since knockout of Nlrp3, Asc, or caspase‐1 but not Aim2 through CRISPR‐Cas9 technique in DC2.4 cells markedly decreased the protein level of IL‐1β induced by the Arf1‐ablated tumor cells (Figure 1a and Figure S1e,f, Supporting Information). The gene discussed is ARF1; the disease is neoplasm.