We first knocked out Cd36, Tlr2, or Tlr6 in DCs by CRISPR‐Cas9 technique and found that the ASC speck formation was significantly reduced in the Cd36CRISPR‐/−, Tlr2CRISPR‐/− or Tlr6CRISPR‐/− DCs in comparison with that in wild‐type DCs after co‐culture with the Arf1‐ablated tumor cells (Figure S10b–d, Supporting Information). This evidence concerns the gene TLR6 and neoplasm.