All ETS transcription factors possess highly conserved DNA binding ETS domains that recognize the common core DNA motif 5′‐GGA(A/T)−3′, yet they still vary in DNA binding specificity and regulate distinct target genes.[22] The DNA binding specificity of each ETS member could be affected by many other DNA binding proteins that interact with ETS transcription factors.[22] In this study, we identified the known oncogenic transcription factors SP1 and SP3, instead of SRF, as the primary functional partners of ELK4 at the genome‐wide level in CRC. This evidence concerns the gene SP3 and colorectal carcinoma.