To identify the direct target gene cooperatively regulated by ELK4 and SP1/3 to enhance tumor angiogenesis, we also generated the gene transcription profiles of SP1/3 knockdown HCT116 cells by RNA‐seq and found a marked overlap of genes that were differentially expressed by ELK4 knockdown or SP1/3 knockdown (P < 0.05) (Figure 5A). The gene discussed is SP1; the disease is neoplasm.