In addition, the levels of LRG1 in the plasma and urine have been identified as biomarkers for presurgical diagnosis in a broad range of malignancies.[31] Given that the serum LRG1 protein level is increased in CRC, we propose that the serum LRG1 protein level could be a biomarker for treatment based on targeting the ELK4‐SP1/3 complex. Here, SP1 is linked to colorectal carcinoma.