SP1 has been reported to cooperate with another ETS transcription factor, ETS1, to transactivate the expression of target genes, such as PDGF‐A, PTHrP and DHX15.[26] These previous studies focused on a specific target gene; however, we describe a comprehensive genome‐wide cooperative DNA binding and gene transcription regulation mechanism between ELK4 and SP1/3 in CRC. The gene discussed is PTHLH; the disease is colorectal carcinoma.