Integrated genomics‐ and proteomics‐based approaches (ChIP‐seq, RNA‐seq, and IP‐MS analysis) identified the transcription factors SP1 and SP3 as novel coregulators of ELK4 at the genome‐wide level in CRC, instead of SRF, the well‐known cofactor of ELK4. Here, ELK4 is linked to colorectal carcinoma.