It has been reported that ERK can phosphorylate SP1 to promote its nuclear translocation.[20] However, we did not observe the subcellular translocation of SP1 upon serum stimulation and U0126 treatment in CRC cells (Figure S5D, Supporting Information), which further suggested that the diminished ELK4‐SP1 interaction by MEK‐ERK inhibition was not due to the reduced level of nuclear SP1 protein. This evidence concerns the gene ELK4 and colorectal carcinoma.