SRF and colorectal carcinoma: Both ELK1 and ELK4 are well known as transcriptional coregulators of SRF and are thought to function primarily by complexing with SRF.[22] However, the expression of c‐fos, the well‐known direct target of ELK1/4 through its complex with SRF, was not affected by knockdown of ELK4 in CRC cells.