An intriguing possibility explaining the higher content in ACE2 specifically in the TBS fraction, as detected with an antibody targeting the N-terminal extracellular domain, could be an enhanced release of ACE2 from the membrane to the cytosol or the extracellular parenchyma in AD, also termed ACE2 shedding [37, 85]. The gene discussed is ACE2; the disease is Alzheimer disease.