NPR2 and polycystic ovary syndrome: In addition, researchers have reported that LH upregulated the expression of the NPPC/NPR2 system in ovarian granulosa cells from mice with PCOS and granulosa cell lines cultured in vitro through the binding of androgens and estrogens to their respective receptors, and inhibited MI resumption by elevating cGMP levels in CGCs [45, 46].