Similar to HIF1A and ADAM10, circ_0000977 expression was induced by hypoxia in a concentration-dependent manner in Panc-1 cells, significantly increasing sMICA level in the supernatant, suggesting that circ 0000977, HIF1A, and ADAM10 expressions are all highly increased in PC tissues [85]. Here, ADAM10 is linked to pachyonychia congenita.