More recently, T-cell immunoglobulin mucin 3 and T-cell immunoglobulin mucin 4 (TIM-3 and TIM-4) have been used as markers of histiocytic and dendritic neoplasms; however, due to their expression on dendritic cell neoplasms, Langerhans cell histiocytosis, and cases of acute monocytic leukemia, they might not be an ideal marker for confirmation of HS disease [11]. This evidence concerns the gene TIMD4 and acute monocytic leukemia.